娘だけのお父さん,癌に注意
News Release from Columbia University Mailman School of Public Health on January 2, 2007.
(C)2004 CAHILUS
息子を持たず,娘しかいないお父さんは前立腺癌になりやすいらしい。子供の性別と前立腺癌の関係を調べたこのユニークな研究では,イスラエル在住の父親約39,000人について,子供の誕生(1964~76年)から約30年間にわたる長期追跡調査が行われた(2005年に終了)。息子がいないと前立腺癌の危険性が40%高くなり,息子の数が多いほど危険性は低かった。男の子が生まれるには父親からY染色体を受け継ぐ必要があるが,父親のY染色体に障害がある場合,男の子が生まれにくく,前立腺癌の発生にも影響すると考えられている。(吉田素子)
In a new and unique study to determine if(1) genes(2) on the Y chromosome(3) are involved in(4) prostate cancer(5), researchers at Columbia University's Mailman School of Public Health(6) in conjunction with(7) Hebrew University of Jerusalem found that men who had only daughters had a higher risk of(8) prostate cancer than men who had at least(9) one son, thus signifying(10) a possible defect(11) on the father's Y chromosome. The results, published in the January 3, 2007 issue of the Journal of the National Cancer Institute(12), further indicate that the relative risk(13) of prostate cancer decreases as the number of sons increases.
The researchers in the Mailman School's Department of Epidemiology(14) analyzed the relative risk of prostate cancer by the sex of offspring(15) among fathers registered in a family-based research cohort(16) in Israel. From this cohort of 38,934 men, followed(17) from the birth of their offspring (in 1964 through 1976) until 2005, the authors conclude that genes on the Y chromosome may be involved in prostate cancer risk in this population.
"We surveyed vital status(18) and cancer incidence(19), and found a strong trend for(20) a decrease in prostate cancer risk as the number of sons increased," said Susan Harlap, MD, professor of clinical Epidemiology at the Mailman School of Public Health, and the leader of the research team. "We anticipate(21) that this finding will have a significant impact on(22) the direction of research(23) in this field going forward(24)." Overall, there was a 40% increase in prostate cancer in men lacking sons(25).
(1) ~かどうか判定する (2) 遺伝子 (3) 染色体 (4) ~に関与する (5) 前立腺癌
(6) 公衆衛生大学院 (7) ~と協力して (8) ~の危険性が高い (9) 少なくとも
(10) 示す (11) 欠陥 (12) 国立癌研究所 (13) 相対リスク (14) 疫学部 (15) 子供
(16) 家族ベースの研究コホート (17) 追跡された (18) 生命状態(生死) (19) 癌発生率
(20) ~という傾向が強いことを発見した (21) 予測する (22) ~に大きな影響を及ぼす
(23) 研究の方向性 (24) いずれ (25) 息子のいない男性