Weekly Topic

(c) Universitat Autònoma de Barcelona
研究班と記事の執筆者Pierre Caufapé氏


UAB Researchers Cure Type 1 Diabetes in Dogs

Researchers at the Universitat Autònoma de Barcelona have succeeded in completely curing type 1 diabetes in dogs with a single session of gene therapy. This is the first time that the disease has been cured in large animals, a fundamental step towards applying the therapy in humans. The study, based on introducing a "glucose sensor" into muscle, has been published in Diabetes, the most prestigious journal in this field. 

Researchers from the Universitat Autònoma de Barcelona (UAB), led by Fàtima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. As published this week in Diabetes, the principal journal for research on the disease, after a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease. In some cases, monitoring continued for over four years, with no recurrence of symptoms.

The therapy is minimally invasive. It consists of a single session of various injections in the animal's rear legs using simple needles that are commonly used in cosmetic treatments. These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other. Glucokinase is an enzyme that regulates the uptake of glucose from the blood. When both genes act simultaneously they function as a "glucose sensor", which automatically regulates the uptake of glucose from the blood, thus reducing diabetic hyperglycemia (the excess of blood sugar associated with the disease).

Researchers:研究者 Type 1 Diabetes:I型糖尿病
gene therapy:遺伝子治療 fundamental:根本的な introducing ~ into …:~を…に差し込む glucose sensor:グルコースセンサー prestigious:権威のある
symptoms:症状 In some cases:一部の症例では recurrence:再発
minimally invasive:侵襲が最小限である injections:注射 rear legs:後ろ足 commonly:一般に cosmetic treatments:美容整形術 vectors:ベクター dual:二つの objective:目的 express:~を発現させる insulin:インスリン ~ on the one hand, …on the other:一方~で,他方…である glucokinase:グルコキナーゼ enzyme:酵素 regulates:~を制御する uptake:取り込み simultaneously:同時に automatically:自動的に diabetic hyperglycemia:糖尿病性高血糖 blood sugar:血糖 associated with:~と関連した



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