Weekly Topic

(c) UT Southwestern Medical Center
研究を行ったDr. David Mangelsdorf(左)とDr. Steven Kliewer


Researchers Find Potential New Non-insulin Treatment for Type 1 Diabetes

Researchers at UT Southwestern Medical Center have discovered a hormone pathway that potentially could lead to new ways of treating type 1 diabetes independent of insulin, long thought to be the sole regulator of carbohydrates in the liver. Results of this new study will be published March 25 in Science.

Another hormone, fibroblast growth factor 19 (FGF19), has insulin-like characteristics beyond its role in bile acid synthesis. Unlike insulin, however, FGF19 does not cause excess glucose to turn to fat, suggesting that its activation could lead to new treatments for diabetes or obesity.

“The fundamental discovery is that there is a pathway that exists that is required for the body, after a meal, to store glucose in the liver and drive protein synthesis. That pathway is independent of insulin,” said Dr. David Mangelsdorf, chairman of pharmacology at UT Southwestern.

Naturally elevating this pathway, therefore, could lead to new diabetes treatments outside of insulin therapy. The standard treatment for type 1 diabetes, which affects about 1 million people in the U.S., involves taking insulin multiple times a day to metabolize blood sugar.

Dr. Mangelsdorf and Dr. Steven Kliewer, professor of molecular biology and pharmacology at UT Southwestern, are co-senior authors of the study. Dr. Kliewer has been studying the hormone FGF19 since he discovered its involvement in metabolism about eight years ago.

Fibroblast growth factors control nutrient metabolism and are released upon bile acid uptake into the small intestine. Bile acids, produced by the liver, break down fats in the body.

Researchers:研究者 Non-insulin:非インスリンの~ Type 1 diabetes:I型糖尿病
hormone pathway:ホルモン経路 potentially:可能性を秘めた lead to:~につながる independent of:~とは無関係に sole:唯一の regulator:制御因子 carbohydrates:炭水化物 liver:肝臓
fibroblast growth factor:線維芽細胞増殖因子 insulin–like:インスリンの様な bile acid:胆汁酸 synthesis:合成 glucose:グルコース(ブドウ糖) activation:活性化 obesity:肥満
protein:タンパク質 pharmacology:薬理学
elevating:亢進させること therapy:治療 metabolize:代謝する blood sugar:血糖
molecular biology:分子生物学 co-senior authors:共同主席著者 involvement:関与metabolism:代謝
nutrient:栄養素の are released:放出される uptake:取り込み small intestine:小腸 break down:分解する



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